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Biomedicine and Society Online 8 (2019): 1—6. URL: https://doi.Org/10.1016/j. rbms.2018.11.002.

[19] Johnson, Elder. The Oldham Notebooks, 46—57.

[20] Wilson. The Making of British Bioethics, 154.

[21] «Законодательное регулирование ЭКО». Баронесса Мери Варнок, интервью с Роджером Хайфильдом для Музея науки, 4 июня 2018 года, видео, 19:19, https://youtu.be/phwVo-W-G_l.

[22] Wilson, The Making of British Bioethics, 140.

[23] Ibid.

[24] Ingmar Persson. Two Claims About Potential Human Beings. Bioethics 17. Nos. 5—6 (2003): 503—517. Doi: https://doi.org/10.lll/1467-8519.00364.

[25] Баронесса Мери Варнок, электронное письмо Роджеру Хай-филду, 21 января 2019 года.

[26] «Законодательное регулирование ЭКО», https://youtu.be/phwVo-W-G_I.

[27] Mary Warnock and the Committee of Inquiry into Human Fertilisation and Embryology, Department of Health and Social Security. Report of the Committee of Inquiry into Human Fertilisation and Embryology, July 1984 (London: Her Majesty’s Stationery Office, 1988). Copy on the Human Fertilisation and Embryology Authority website. URL: www. hfea.gov.uk/media/2608/wamock-report-of-the-committee-of- in-quiry-into-humanfertilisation-and-embryology-1984.pdf.

[28] «Законодательное регулирование ЭКО», https://youtu.be/phwVo-W-GI.

[29] В основном это заслуга невролога Джона Уолтона. «Законодательное регулирование ЭКО», https://youtu.be/phwVo-W-G_I.

[30] «Законодательное регулирование ЭКО», https://youtu.be/phwVo-W-GJ.

[31] Stem Cell Research and Regulations Under the Human Fertilisation and Embryology Act /99(7 (Revised Edition). House of Commons Library, www.files.ethz.ch/isn/44586/rp00-093.pdf.

[32] Fetal Awareness: Review of Research and Recommendations for Practice. Royal College of Obstetricians & Gynaecologists, June 25, 2010, accessed April 4, 2019. URL: www.rcog.org.uk/en/guidelines-re-search-services/guidelines/fetal-awareness—-review-of-research-and-recommendations-for-practice.

[33] R. C. Tyser, A. M. Miranda, C. Chen, S. M. Davidson, S. Srinivas, R R. Riley. Calcium Handling Precedes Cardiac Differentiation to Initiate the First Heartbeat. eLife 5 (2016): e 17113. Doi: 10.7554/ eLife.17113.

134] Roger Highfield. First IVF Baby Louise Brown Celebrates 40th at the Science Museum. Science Museum blog, July 26, 2018, accessed April 4,2019. URL: https://blog.sciencemuseum.org.uk/firstivf-baby-louise-brown-celebrates-40th-at-the-science-museum/.

[35] J. Benjamin Hurlbut. Experiments in Democracy: Human Embryo Research and the Politics of Bioethics. New York: Columbia University Press, 2017.

[36] Amy Lee, Ann A. Kiessling. Early Human Embryos Are Naturally An-euploid—Can That Be Corrected? Journal of Assisted Reproduction and Genetics 34. No. 1 (2016): 15-21. Doi: 10.1007/sl0815-016-0845-7.

Глава 8. Саймон

[1] S. Santaguida, A. Tighe, A. M. D’Alise, S. S. Taylor, A. Musac-chio. Dissecting the Role of MPS1 in Chromosome Bi orientation and the Spindle Checkpoint Through the Small Molecule Inhibitor Reversine. Journal of Cell Biology 190 (2010): 73—87.

[2] А. К. Hadjantonakis, V. Е. Papaioannou. Dynamic In Vivo Imaging and Cell Tracking Using a Histone Fluorescent Protein Fusion in Mice. BMC Biotechnology (2004).

[3] Florence Wianny, Magdalena Zernicka-Goetz. Specific Interference with Gene Function by Double-Stranded RNA in Early Mouse Development. Nature Cell Biology 2 (1999): 70—75.

[4] H. Bolton, S. J. L. Graham, N. Van der Aa, P. Kumar, K. Theunis,

E. Fernandez Gallardo, T. Voet, M. Zernicka-Goetz. Mouse Model of Chromosome Mosaicism Reveals Lineage-Specific Depletion of Aneuploid Cells and Normal Developmental Potential. Nature Communications 7 (2016): 11165. Doi:10.1038/ncommsl 1165.

[5] Maria-Elena Torres-Padilla, David-Emlyn Parfitt, Tony Kouzarides, Magdalena Zernicka-Goetz. Histone Arginine Methylation Regulates Pluripotency in the Early Mouse Embryo. Nature 445 (2007): 214—218. Doi:10.1038/nature05458.

Глава 9. Как синтезировать эмбрион

[1] С. R. Woese. A New Biology for a New Century. Microbiology and Molecular Biology Reviews 68. No. 2 (2004): 173-186.

[2] Leroy C. Stevens Jr., С. C. Little. Spontaneous Testicular Teratomas in an Inbred Strain of Mice. Proceedings of the National Academy of Sciences 40 (1954): 1080-1087.

[3] L. C. Stevens. Embryonic Potency of Embryoid Bodies Derived from a Transplantable Testicular Teratoma of the Mouse. Developmental Biology 2 (1960): 285-297.

[4] G. B. Pierce, F. J. Dixon. Testicular Teratomas. I. Demonstration of Teratogenesis by Metamorphosis of Multipotential Cells. Cancer 12 (1959): 573-583.

[5] Martin Evans. Origin of Mouse Embryonal Carcinoma Cells and the Possibility of Their Direct Isolation into Tissue Culture. Journal of Reproduction and Fertility 62 (1981): 625—631, https://doi.org/10.1530/ jrf.0.0620625.

[6] M. J. Evans, M. FI. Kaufman. Establishment in Culture of Pluripotential Cells from Mouse Embryos. Nature 292 (1981): 154—156.

[7] G. R. Martin. Isolation of a Pluripotent Cell Line from Early Mouse Embryos Cultured in Medium Conditioned by Teratocarcinoma Stem Cells. Proceedings of the National Academy of Sciences 78. No. 12 (1981): 7634-7638.

[8] D. ten Berge, W. Koole, C. Fuerer, M. Fish, E. Eroglu, R. Nusse. Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies. Cell Stem Cell 3. No. 5 (2008): 508-518. Doi: 10.1016/j. stem.2008.09.013.

[9] I. Bedzhov, M. Zernicka-Goetz. Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation. Cell 156 (2014): 1032-1044. Doi: 10.1016/j.cell.2014.01.023.

[10] Ibid.

[11] Susanne C. van den Brink, Peter Baillie-Johnson, Tina Balayo, An-na-Katerina Fladjantonakis, Sonja Nowotschin, David A. Turner, Alfonso Martinez Arias. Symmetry Breaking, Germ Layer Specification and Axial Organisation in Aggregates of Mouse Embryonic Stem Cells. Development 141 (2014): 4231—4242. Doi:10.1242/dev.l 13001.

[12] D. ten Berge, W. Koole, C. Fuerer, M. Fish, E. Eroglu, R. Nusse. Wnt Signaling Mediates Self-Organization and Axis Formation in Embry oid Bodies. Cell Stem Cell 3. No. 5 (2008): 508-518. Doi: 10.1016/j. stem.2008.09.013.

[13] R. S. Beddington, P. Rashbass, V. Wilson. Brachyury — A Gene Affecting Mouse Gastrulation and Early Organogenesis. Development Supplement (1992): 157-165.

[14] S. E. Flarrison, B. Sozen, N. Christodoulou, C. Kyprianou, M. Zernicka-Goetz. Assembly of Embryonic and Extraembryonic Stem Cells to Mimic Embryogenesis In Vitro. Science 356 (2017): eaall810. Doi: 10.1126/science.aall810.

[15] N. C. Rivron, J. Frias-Aldeguer, E. J. Vrij, J.-C. Boisset, J. Korving, J. Vivid, R. K. Truckenmiiller, A. van Oudenaarden, C. A. van Blit-terswijk, N. Geijsen. Blastocyst-Like Structures Generated Solely from Stem Cells. Nature 557 (2018): 106-111. Doi: 10.1038/s41586-018-0051-0.

[16] B. Sozen, G. Amadei, A. Cox, R. Wang, E. Na, S. Czukiewska, L. Chappell, T. Voet, G. Michel, N. Jing, D. M. Glover, M. Zer-nicka-Goetz. Self-Assembly of Embryonic and Two Extra-Embryonic Stem Cell Types into Gastrulating Embryo-Like Structures. Nature Cell Biology 20 (2018): 979-989. Doi: 10.1038/s41556-018-0147-7.

[17] Martin A. N owak. Five Rules for the Evolution of Cooperation. Science 314(2006): 1560-1563. Doi: 10.1126/science.l 133755.

[18] Why Mouse Matters. National Human Genome Research Institute, accessed April 5, 2019. URL: www.genome.gov/10001345/impor-tance-of-mouse-genome/.

[19] Nicolas Rivron, Martin Pera, Janet Rossant, Alfonso Arias, Magdalena Zernicka-Goetz, Jianping Fu, Susanne Van den Brink, Annelien Bredenoord, Wybo Dondorp, Guido de Wert,

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